Arid1b haploinsufficiency in pyramidal neurons causes cellular and circuit changes in neocortex but is not sufficient to produce behavioral or seizure phenotypes
Alec H. Marshall, Meretta A. Hanson, Danielle J. Boyle, Devipriyanka Nagarajan, Noor Bibi, Julie Fitzgerald, Emilee Gaitten, Olga N. Kokiko‐Cochran, Bin Gu, Jason C. Wester
This study shows that Arid1b haploinsufficiency in excitatory neurons alters membrane properties and synaptic connectivity but does not cause social or seizure phenotypes.
bioRxiv · Jun 4, 2024 · PreprintNeuroscience