Bin Gu

Unbiased Long-Read Whole-Genome Sequencing Enables High-Resolution Mapping of Transgene Concatenation and Off-target Genomic Disruption in a Mouse Model

The paper uses long-read sequencing to detect transgene concatenation and off-target integration in a mouse model, revealing hidden genomic complexity and phenotypic disruption.

Behavior decoding delineates seizure microfeatures and associated sudden death risks in mice

AI-aided behavior decoding identifies seizure microfeatures and SUDEP risks in mice using machine learning tools.

The Updated Mouse Universal Genotyping Array Bioinformatic Pipeline Improves Genetic QC in Laboratory Mice

The paper updates the MiniMUGA genotyping array's bioinformatic pipeline to enhance genetic QC in laboratory mice by improving marker annotation, consensus genotypes, and report usability.

Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice

The paper identifies early high-amplitude rhythmic spikes in the hippocampus of mice after traumatic brain injury as predictive of post-traumatic epilepsy.

Arid1b haploinsufficiency in pyramidal neurons causes cellular and circuit changes in neocortex but is not sufficient to produce behavioral or seizure phenotypes

This study shows that Arid1b haploinsufficiency in excitatory neurons alters membrane properties and synaptic connectivity but does not cause social or seizure phenotypes.

A Cas9-fusion proximity-based approach generates an Irak1-Mecp2 tandem duplication mouse model for the study of MeCP2 duplication syndrome.

This paper describes a CRISPR/Cas9-based method to create a mouse model with a tandem duplication of Irak1 and Mecp2, which exhibits MDS-like neurological and immune phenotypes.

Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

Collaborative Cross Mouse Populations as a Resource for the Study of Epilepsy

The paper uses Collaborative Cross mice to identify genetic loci and candidate genes associated with epilepsy traits, providing resources for studying seizure outcomes and developing new therapies.