Computationally guided design of a metastasis-on-a-chip platform for quantitative evaluation of chemotactic cues in developmental cancers
Catherine Murphy, Luka Jarc, Alessia Cadavere, Emilia Cioffi, Maider Badiola-Mateos, David Fernandez, Nathalia Gomez-Jimenez, Jaume Mora, Josep Samitier, Aránzazu Villasante
This paper develops a computationally guided metastasis-on-a-chip platform to evaluate chemotactic cues in cancer cells, finding that VEGF-C promotes migration in Ewing sarcoma and osteosarcoma while VEGF-A165 has no effect.
bioRxiv · Jul 27, 2026 · PreprintBioengineering