Jaume Mora

mRNA deep sequencing profiling and integrative miRNA-mRNA network analysis in pediatric Burkitt leukemia and lymphoma

This study profiles mRNA and miRNA expression in pediatric Burkitt leukemia and lymphoma, identifying dysregulated miRNA-mRNA networks and key pathways involved in proliferation and immune signaling.

Ancient and Animal-Specific Regulatory Modes of EWS::FLI1 Revealed by a Minimal Yeast Model.

This paper shows EWS::FLI1 can activate GGAASat sequences into enhancers in yeast, suggesting this function is ancient, while broader transcriptome changes require animal-specific factors.

RERE and the Mediator complex cooperate with EWSR1::FLI1 in the reprogramming of Translation and Alternative Splicing, the latter being a therapeutically targetable vulnerability in Ewing sarcoma

This paper identifies MED13L and RERE as genes regulated by EWSR1::FLI1 in Ewing sarcoma, showing their role in altering translation and alternative splicing, and demonstrates RBM39 inhibition as a therapeutic strategy.

Computationally guided design of a metastasis-on-a-chip platform for quantitative evaluation of chemotactic cues in developmental cancers

This paper develops a computationally guided metastasis-on-a-chip platform to evaluate chemotactic cues in cancer cells, finding that VEGF-C promotes migration in Ewing sarcoma and osteosarcoma while VEGF-A165 has no effect.

The Drosophila FET orthologue Cabeza is an essential cofactor for ETV4-mediated activation of GGAA microsatellite neoenhancers

The paper identifies Cabeza as a necessary cofactor for ETV4-mediated activation of GGAA microsatellite enhancers in Drosophila, showing distinct mechanisms from EWS::FLI1.

3D neuroblastoma models expose divergent responses to magnetic hyperthermia and photothermal therapy

This study compares photothermal therapy and magnetic hyperthermia in 3D neuroblastoma models, finding that magnetic hyperthermia provides more uniform heating and proliferation control, while photothermal therapy shows variable effects and can paradoxically increase proliferation.

USP7 sustains PAX3::FOXO1 enhancer reprogramming and represents a therapeutic vulnerability in Rhabdomyosarcoma

This study identifies USP7 as a critical regulator of PAX3::FOXO1 enhancers in FP-RMS and shows its inhibition reduces tumor growth.

Integrative multi-omics reveals PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma.

This study identifies PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma through multi-omics analyses and functional experiments.

EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing Sarcoma

This study shows that EWS-FLI1 expression in human embryonic mesenchymal stem cells leads to an ES-like transcriptome and tumor formation, despite not preferentially binding promoters.

Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human disease

The paper develops a preclinical model of PI3K-driven vascular malformations and shows that low-dose AKT inhibitor miransertib prevents and regresses these malformations in mice and human endothelial cells.