Testis-Specific MAGEA3/6 Regulate Glycolysis to Promote Metabolic Flexibility and Reveal Therapeutic Vulnerabilities in Pancreatic Cancer Cells
Sima Tozandehjani, Vesna Jurjevič, Barbara Breznik Vittori, Juan Sebastián Solano-Gutiérrez, Rebecca R. Florke Gee, Denis Štepihar, Maria Camila Hoyos Sanchez, Sara Uhan, Jerneja Koren, Lara Snoj, Emily Ballard, Jesenia M. Perez, Menglin Jiang, Miloš Vittori, Patrick Ryan Potts, Klementina Fon Tacer
This study shows that MAGEA3/6 proteins in pancreatic cancer cells enhance metabolic flexibility by regulating glycolysis and mitochondrial metabolism, revealing therapeutic vulnerabilities.
bioRxiv · Oct 21, 2026 · PreprintCancer Biology