An FGF Timer for Zygotic Genome Activation
Nicholas Treen, Emily Chavarria, Claire J. Weaver, Clifford P. Brangwynne, Michael Levine
The paper studies the timing of zygotic genome activation in Ciona intestinalis using FGF signaling and finds that two Prdm1 homologs are the earliest genes induced, with a sharp transition in FGF responsiveness between 8- and 16-cell stages.
bioRxiv · Oct 1, 2022Developmental Biology