Author
Princeton UniversityORCID 0000-0002-4543-6284Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Yurong Liu, Keita Yoshida, Akiko Hozumi, Kosuke Itagaki, Nicholas Treen, Tetsushi Sakuma, Takashi Yamamoto, Toshinori Endo, Yasunori Sasakura
This study shows Hox2 is required for atrial siphon fusion in Ciona, with Hox2-knockout animals retaining two siphons and lacking cupular organs.
Development Growth & Differentiation · Oct 1, 2026Peer-reviewedDevelopmental Biology
Emily Singer, Haram Kim, Michael Levine, Nicholas Treen
The paper shows that cell number control via Cdkn1.b in Ciona embryos affects cell fate, leading to heart development failure when cell division is arrested early.
Proceedings of the National Academy of Sciences · Jan 8, 2026Peer-reviewedDevelopmental Biology
Nicholas Treen, Emily Chavarria, Claire J. Weaver, Clifford P. Brangwynne, Michael Levine
The paper studies the timing of zygotic genome activation in Ciona intestinalis using FGF signaling and finds that two Prdm1 homologs are the earliest genes induced, with a sharp transition in FGF responsiveness between 8- and 16-cell stages.
bioRxiv · Oct 1, 2022Developmental Biology
Claire J. Weaver, Aleena L. Patel, Stanislav Y. Shvartsman, Michael Levine, Nicholas Treen
The paper shows ERK signaling dissolves ERF repression condensates in Ciona embryos through dynamic phase separation regulated by cell signaling.
Proceedings of the National Academy of Sciences · Feb 25, 2022Peer-reviewedDevelopmental Biology
Nicholas Treen, Shunsuke F. Shimobayashi, Jorine M. Eeftens, Clifford P. Brangwynne, Michael Levine
The paper investigates the role of liquid-liquid phase separation in transcriptional repression by studying Hes/Gro complexes in Ciona embryos and their behavior during cell cycles.
Nature Communications · Mar 10, 2021Peer-reviewedDevelopmental Biology