Targeting ion channel TRPM7 promotes the thymic development of Regulatory T cells by increasing IL-2-dependent STAT5 activation
Suresh K. Mendu, Michael S. Schappe, Emily K. Moser, Julia K. Krupa, Jason S. Rogers, Eric J. Stipes, Clare A. Parker, Thomas J. Braciale, Bimal N. Desai
This study shows that inhibiting TRPM7 increases Treg cell development by enhancing IL-2-dependent STAT5 activation and Foxp3 expression.
bioRxiv · May 25, 2018 · PreprintImmunology