The role of cohesin loading at enhancers in the flux of loop extrusion and long-range transcriptional control
Erika C. Anderson, Hadi Rahmaninejad, Abrar Aljahani, Emily M. Arnold, Annie S. Adachi, Rini Shah, Karissa L. Hansen, Ivana Cavka, Alistair Nicol Boettiger, Geoffrey Fudenberg, Elphège Pierre Nora
This study shows that cohesin loading at enhancers does not significantly contribute to genome folding or long-range transcriptional control, as inhibiting cohesin recruitment near enhancers reduces target promoter transcription.
bioRxiv · Feb 7, 2026 · PreprintMolecular Biology