Author

Ivana Čavka

Heidelberg UniversityORCID 0000-0002-2640-8587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 2 Assay:imaging· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Simone KöhleriD· 4 shared Ana Rita Rodrigues NevesiD· 2 shared Cristina Piñeiro LópeziD· 2 shared Jonas RiesiD· 2 shared Yule WuiD· 2 shared Abrar AljahaniiD· 1 shared Alexander WoglariD· 1 shared Alistair Nicol BoettigeriD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCell Biology

Simone KöhlerORCID

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5 papers

Recent·Most cited

SpotMAX: a generalist framework for multi-dimensional automatic spot detection and quantification

Francesco Padovani, Ivana Čavka, Ana Rita Rodrigues Neves, Cristina Piñeiro López, Nada Al-Refaie, Leonardo Bolcato, Dimitra Chatzitheodoridou, Yagya Chadha, Pablo Lagos, Timon Stegmaier, Xiaofeng A. Su, Jette Lengefeld, Daphne S. Cabianca, Simone Köhler, Kurt M. Schmoller

SpotMAX is an AI-driven framework for automated spot detection and quantification in microscopy data, outperforming existing tools and human annotators across diverse biological applications.

Science Advances · Jul 8, 2026Peer-reviewedCell Biology

The role of cohesin loading at enhancers in the flux of loop extrusion and long-range transcriptional control

Erika C. Anderson, Hadi Rahmaninejad, Abrar Aljahani, Emily M. Arnold, Annie S. Adachi, Rini Shah, Karissa L. Hansen, Ivana Cavka, Alistair Nicol Boettiger, Geoffrey Fudenberg, Elphège Pierre Nora

This study shows that cohesin loading at enhancers does not significantly contribute to genome folding or long-range transcriptional control, as inhibiting cohesin recruitment near enhancers reduces target promoter transcription.

bioRxiv · Feb 7, 2026 · PreprintMolecular Biology

Multi-step implementation of meiotic crossover patterning

Ivana Čavka, Alexander Woglar, Yule Wu, Emine Berna Durmus, Lauren M. Sloat, Oane Gros, Cristina Piñeiro López, Felix Hecht, Anne M. Villeneuve, Jonas Ries, Simone Köhler

The paper investigates the timing and mechanism of crossover designation in C. elegans using advanced imaging techniques, revealing a multi-step, dynamic regulation process.

bioRxiv · Nov 12, 2025 · PreprintCell Biology

Crossovers are regulated by a conserved and disordered synaptonemal complex domain

Ana Rita Rodrigues Neves, Ivana Čavka, Tobias Rausch, Simone Köhler

The paper identifies a conserved, disordered domain in SYP-4 that regulates crossover assurance and interference in meiosis by recruiting an E3 ligase.

Nucleic Acids Research · Feb 4, 2025Peer-reviewedCell Biology

Global fitting for high-accuracy multi-channel single-molecule localization

Yiming Li, Wei Shi, Sheng Liu, Ivana Čavka, Yule Wu, Ulf Matti, Decheng Wu, Simone Köhler, Jonas Ries

This paper introduces globLoc, a GPU-based global fitting algorithm for multi-channel single-molecule localization, improving 3D precision and color assignment in SMLM.

Nature Communications · Jun 6, 2022Peer-reviewedMolecular Biology