Erika C. Anderson

The paper develops a framework to correct cohesin positioning measurements in ChIP-seq by accounting for antibody background, revealing its impact on cohesin positioning estimates.

This study shows that cohesin loading at enhancers does not significantly contribute to genome folding or long-range transcriptional control, as inhibiting cohesin recruitment near enhancers reduces target promoter transcription.

The paper shows that the extrusion rate of cohesin is tunable by cofactor dosage and buffers chromosome structure against genetic disruption.

This study shows that cohesin is not always necessary for enhancer function, as some enhancers can act independently through synergy or insulators.