Karissa L. Hansen

This study proposes that cohesin bridging, not spatial proximity, mediates enhancer-promoter communication and develops a model to validate this mechanism through engineered cell systems.

This study shows that cohesin loading at enhancers does not significantly contribute to genome folding or long-range transcriptional control, as inhibiting cohesin recruitment near enhancers reduces target promoter transcription.

The paper shows that the extrusion rate of cohesin is tunable by cofactor dosage and buffers chromosome structure against genetic disruption.

The paper investigates the relationship between palatal segment growth and midfacial anterior-posterior elongation in mice, showing a one-to-one correspondence between palatal segments and upper jaw bones.

This study shows that cohesin is not always necessary for enhancer function, as some enhancers can act independently through synergy or insulators.

The paper identifies a SNP that regulates facial shape and disease risk by affecting PKDCC expression during chondrogenesis, showing its impact on both normal variation and clefting.