Durable and reversible epigenetic programming of human hematopoietic stem cells as a platform for modulation of platelet function
Tianyi Ye, Wanying Xu, María N. Barrachina, Peng Lyu, Mateusz Antoszewski, Lucrezia della Volpe, C. Guo, Andrew Lee, Emily Villalpando, Issac A. Johnson, Madelaine Skolastika Theardy, Spencer D. Shelton, Lara Wahlster, Alexis Caulier, Luana Messa, , Vijay G. Sankaran
This study uses DNA methylation-based epigenome editing to durably and reversibly silence genes in human hematopoietic stem cells, demonstrating its application in modulating platelet function.
bioRxiv · Oct 8, 2026 · PreprintGenomics