C. Guo

This study uses DNA methylation-based epigenome editing to durably and reversibly silence genes in human hematopoietic stem cells, demonstrating its application in modulating platelet function.

This study identifies a BACH2-NRF2 axis regulating fetal hemoglobin activation through genetic and functional analyses in a large multi-ancestry cohort.

The paper identifies 'matchmaker' cis-regulatory elements in erythropoiesis that strengthen loops between neighboring elements and are linked to gene expression and cohesin loading.

This study maps genetic risk mechanisms for immune-mediated diseases by integrating single-cell multi-omic data with fine-mapped variants from genome-wide association studies.

The paper identifies a genetic variant associated with reduced blood counts and cancer protection, showing it disrupts a lncRNA that regulates HOXA gene expression in hematopoietic stem cells.

The paper identifies a genetic variant that protects against clonal hematopoiesis by regulating RNA-binding protein MSI2 in hematopoietic stem cells.

This paper introduces TDAC-seq, a method combining CRISPR perturbations with chromatin accessibility profiling to study cis-regulatory elements at single-nucleotide resolution.