Andrew Lee

This study uses DNA methylation-based epigenome editing to durably and reversibly silence genes in human hematopoietic stem cells, demonstrating its application in modulating platelet function.

This study identifies a BACH2-NRF2 axis regulating fetal hemoglobin activation through genetic and functional analyses in a large multi-ancestry cohort.

The paper uses single-cell multiomic analysis to identify genetic variants and regulatory disruptions linked to childhood B-cell acute lymphoblastic leukemia.

The paper uses CRISPR and single-cell transcriptomics to study how inherited variants in B-cell development contribute to childhood leukemia.

GEM-Finder identifies disease-associated CREs by integrating transcriptomic, epigenomic, and chromatin interaction data during endothelial differentiation, revealing 7.6 times more associations than conventional methods.

This study identifies cell-type-specific dysregulated cis-regulatory elements and target genes in Parkinson's disease using multi-omic analyses of single-cell transcriptomes and epigenomes.

This study shows that CHD4 regulates chromatin accessibility to hide aberrant CTCF-binding sites within TADs in mESCs, preventing TAD disorganization.

The paper identifies a new class of super-enhancers active across multiple cell/tissue types and links them to fast-recovering 3D chromatin loops.