System-level regulation of hierarchical transitions in a tumour lineage
Emma Legait, Charlotte Rulquin, Lauranne Bouteille, Raphaël Clément, Cédric Maurange
This study identifies a local regulatory mechanism that drives spatial segregation of cancer stem cells in tumors and shows how it constrains their differentiation dynamics.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology