Transcriptomic Analysis of Human Sensory Neurons in Painful Diabetic Neuropathy Reveals Inflammation and Neuronal Loss
Bradford E. Hall, Emma Macdonald, Margaret M. Cassidy, Sijung Yun, Matthew R. Sapio, Pradipta R. Ray, Megan E. Doty, Pranavi Nara, Michael D. Burton, Stephanie I. Shiers, Abhik Ray‐Chaudhury, Andrew J. Mannes, Theodore John Price, Michael J. Iadarola, Ashok B. Kulkarni
The paper identifies 844 differentially expressed genes in DRGs from DPN patients, showing increased inflammation and decreased neuronal genes, suggesting intraganglionic pathology in diabetic neuropathy.
Scientific Reports · Mar 18, 2022Peer-reviewedNeuroscience