Theodore John Price

Prolactin Receptor Long Isoform ΔS1 Expression is Reduced in the Dorsal Root Ganglia of Humans with Chronic Pain

The paper examines PRLR isoform expression in human dorsal root ganglia, finding higher PRLR-L (ΔS1) expression in females and reduced expression in females with chronic pain.

History of opioid use disorder correlates with altered neuroimmune signatures in the human dorsal root ganglia

The paper examines molecular and physiological changes in dorsal root ganglia from individuals with and without opioid use disorder, identifying altered neuroimmune signatures and sensitized sensory neurons.

Leptin Drives Osteoarthritis Pain Through Sensory Neuron Reprogramming Independent of Cartilage Signaling

This study shows leptin drives OA pain via sensory neuron reprogramming, not cartilage signaling, by analyzing mouse models and human datasets.

E-Selectin Orchestrates IL-1B-Dependent Neuroinflammation via NLRP3 in Vincristine-Induced Neuropathy

This study identifies E-selectin as a key driver of IL-1B-dependent neuroinflammation in vincristine-induced neuropathy and suggests targeting E-selectin as a therapeutic strategy.

Chronic lower limb pain is not associated with a loss of inhibitory neurons in the human lumbar spinal dorsal horn

This study examines the anatomical changes in the human lumbar spinal dorsal horn in relation to chronic lower limb pain and finds no association with neuronal density or inhibitory neuron loss.

Antibiotics modulate activity of mouse and human dorsal root ganglia neurons

The paper shows that antibiotics like β-lactams, macrolides, and tetracyclines alter calcium flux in DRG neurons through mechanisms involving extracellular calcium, TRPA1, and mitochondrial ROS.

NaV1.7-dependent peripheral sensitization drives chronic pain in Parkinson's disease

This study identifies NaV1.7-dependent peripheral sensitization as a mechanism of chronic pain in Parkinson's disease and highlights CRMP2 regulation of NaV1.7 as a therapeutic target.

DRG meningeal tertiary lymphoid structures are regulated by B cells as a pronociceptive locus after peripheral nerve injury

The paper shows that B cell-derived IgG in DRG meninges forms tertiary lymphoid structures (TLSs) that drive neuropathic pain after peripheral nerve injury, and disrupting TLSs prevents pain.

Senescent peripheral fibroblasts initiate chemotherapy-induced peripheral neuropathy

This study identifies senescent peripheral fibroblasts as the initiators of chemotherapy-induced peripheral neuropathy, showing that targeting MK2 in these cells can prevent and reverse the condition.

Live cell imaging reveals paclitaxel-induced lysosome motility and function disruption in DRG neurons

This study shows paclitaxel disrupts lysosome motility and function in DRG neurons, and MNK1/2 inhibition with eFT508 restores lysosomal signaling and alleviates CIPN.

Satellite microglia-like cells in human dorsal root ganglia and changes with diabetic neuropathy

The paper identifies microglia-like cells in human dorsal root ganglia and shows their changes in diabetic neuropathy.

T-cell distribution in the dorsal root ganglion across species, sex, and age

The paper investigates T-cell distribution in the dorsal root ganglion across species, sex, and age, finding similar levels in humans, non-human primates, and pigs, but fewer in rats and absent in mice, with sex and age differences in humans.

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons

This study develops a novel method to generate human induced pluripotent stem cell-derived sensory neurons that closely resemble primary human tissue transcriptionally and functionally.

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

Adipose-driven complement-lipid reprogramming controls nociceptive vulnerability in obesity-associated osteoarthritis

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

Nav1.8 mediates peripheral-to-central nociceptive transmission independently of central presynaptic mechanisms in human DRG-spinal cord circuits

This study shows that Nav1.8 blockers reduce spinal CGRP release only when applied to peripheral sites, indicating their mechanism acts at the peripheral level rather than the central nervous system.

Molecular architecture of human dermal sleeping nociceptors

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

The paper identifies neurotrophic signals, particularly FGF9, required for fracture healing by mapping somatosensory afferent circuitry to bone and analyzing gene expression changes in DRG neurons.

Meteorin resolves nociceptive hypersensitivity by reducing connexin-mediated coupling in satellite glial cells

This study shows meteorin reduces nociceptive hypersensitivity by decreasing connexin-mediated coupling in satellite glial cells, with long-lasting therapeutic effects in pain models.

GM-CSF instructs vertebral emergency myelopoiesis in neuropathic pain

This study identifies GM-CSF as a key mediator of vertebral bone marrow emergency myelopoiesis in neuropathic pain, linking meningeal immunity to pain pathogenesis.

Single-nuclei RNA Sequencing Reveals Distinct Transcriptomic Signatures of Rat Dorsal Root Ganglia in a Chronic Discogenic Low Back Pain Model

This study uses single-nuclei RNA sequencing to identify transcriptomic changes in rat dorsal root ganglia in a chronic discogenic low back pain model, linking gene expression to axial hypersensitivity.

A Reference Atlas of the Human Dorsal Root Ganglion

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

Molecular and Functional Asymmetry in Cckar-expressing Vagal Sensory Neurons

The paper identifies a right-biased neuronal population in vagus nerves that expresses genes related to digestive signaling and may contribute to asymmetric reward processing.

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

TrkA+ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression

This study shows that TrkA+ sensory neurons promote osteosarcoma progression by enhancing tumor growth, vascularization, and metastasis, and that inhibiting these neurons reduces disease severity and improves survival.

Detection of probable neuronal gene expression changes in skin biopsies from patients with paclitaxel-induced peripheral neuropathy

The paper investigates neuronal gene expression changes in skin biopsies from paclitaxel-induced peripheral neuropathy patients using bulk RNA sequencing and spatial transcriptomics.

Glutamatergic and GABAergic synapses in the human spinal dorsal horn revealed with immunohistochemistry

This study uses immunohistochemistry to visualize glutamatergic and GABAergic synapses in human spinal cord tissue, showing similarities to rodent models.

Nerve-targeting and pain-promoting transcriptomic signatures in early Guillain-Barre syndrome

This study identifies transcriptomic signatures in GBS patients that reveal leukocyte interactions with peripheral nerves and pain pathways, suggesting therapeutic targets for neuropathic pain.

Enabling wider access to human molecular neuroscience research in pain: A simple preservation method for human dorsal root ganglion neurons in Hibernate A media

This paper introduces a method to preserve human dorsal root ganglion neurons using Hibernate media, enabling easier access and transport for research.