Ashok B. Kulkarni

This study shows that CDK5 activation in human sensory neurons broadens action potentials, suggesting a role in chronic pain mechanisms.

The paper integrates metabolomic, proteomic, and phospho-proteomic analyses of dorsal root ganglia from DPN donors and controls to identify molecular changes associated with diabetic neuropathic pain.

The paper identifies 844 differentially expressed genes in DRGs from DPN patients, showing increased inflammation and decreased neuronal genes, suggesting intraganglionic pathology in diabetic neuropathy.

This study investigates the role of Cdk5 in trigeminal ganglion neuronal signaling and shows that Cdk5 inhibitors reduce pain-related Ca2+ responses and allodynia in mice.