Pradipta R. Ray

The paper identifies 844 differentially expressed genes in DRGs from DPN patients, showing increased inflammation and decreased neuronal genes, suggesting intraganglionic pathology in diabetic neuropathy.

The paper uses RNA sequencing on muscle biopsies from a bed-rest study to show exercise reduces deconditioning-related gene expression changes and ligand-receptor interactions with DRG neurons.

The paper profiles RNA in human DRGs from neuropathic pain patients, identifying sex-specific gene expression differences and neuro-immune pathways associated with pain.

This study conducts a sex-stratified genome-wide association study of multisite chronic pain in UK Biobank, identifying sex-specific genetic loci and highlighting sex differences in chronic pain mechanisms.

The paper compares receptor expression diversity between central and peripheral mouse neurons using single-cell RNA sequencing and finds similar diversity overall, with exceptions in GPCRs and cytokine receptors.

The paper uses spatial transcriptomics to characterize human sensory neurons, comparing them to mouse and non-human primate data to identify similarities and divergences in drug targets.

The paper develops a PAR3 agonist and shows it induces mechanical hypersensitivity in mice, suggesting PAR3's role in nociception and plasticity.

The paper identifies sex differences in nociceptor translatomes, revealing sex-specific prostaglandin signaling differences in male and female mice.

The paper shows that human dorsal root ganglion neurons express ACE2, suggesting they may be a target for SARS-CoV-2 entry into the nervous system.

The paper identifies Arc as an activity-dependent gene involved in neurogenic inflammation through intercellular signaling via extracellular vesicles.

This study identifies a specific subset of sensory neurons expressing PAR2 that mediate mechanical and affective pain behaviors, clarifying the cellular basis of PAR2-evoked pain.

The paper creates interactome maps of ligand-receptor interactions between peripheral cell types and sensory neurons in mouse and human disease states, identifying potential therapeutic targets like EGFR.

The paper compares transcriptomes of native and cultured human and mouse dorsal root ganglia, finding reduced neuronal gene expression in culture but presence of key pharmacological targets.

The paper analyzes human tibial nerve transcriptomes to identify sex-dimorphic gene expression related to pain, inflammation, and neuro-immunity.

The paper identifies the RagA-mTORC1 network as a key driver of neuropathic pain through cell-specific translational profiling in nociceptors.

The paper compares human and mouse dorsal root ganglia transcriptomes using RNA-seq, identifying enriched genes and pathways relevant to pain and sensory neuroscience.

This study identifies macrophage AT2R activation as a key driver of neuropathic pain through ROS/NO-mediated TRPA1 activation in sensory neurons.