De novo designed pMHC binders facilitate T cell induced killing of cancer cells
Kristoffer Haurum Johansen, Darian Stephan Wolff, Beatrice Scapolo, Monica L. Fernández‐Quintero, Charlotte Risager Christensen, Johannes R. Loeffler, Esperanza Rivera‐de‐Torre, Max D. Overath, Kamilla Kjærgaard Munk, Oliver Morell, Marie Christine Viuff, Iñigo Lacunza, A Englund, Mathilde Due, Anant Gharpure, , Timothy P. Jenkins
This paper designs de novo pMHC binders using generative models to create T cell-based cancer therapeutics with high specificity and minimal cross-reactivity.
Science · Jul 24, 2025Peer-reviewedImmunology