Marie Christine Viuff

This study identifies impaired HPV-specific CD8 T cell recognition and a suppressive immune microenvironment in cervical cancer, highlighting the need for enhanced T cell responses and immune suppression targeting.

ITRAP2 improves TCR-pMHC pairing accuracy by reducing noise and cross-contamination in single-cell data, outperforming existing methods on both in-house and public datasets.

This paper designs de novo pMHC binders using generative models to create T cell-based cancer therapeutics with high specificity and minimal cross-reactivity.