Anant Gharpure

IPO9 modulates histone-dependent inhibition of cGAS activity

The paper identifies IPO9 as a regulator of cGAS-STING signaling by releasing cGAS from H2A-H2B dimer inhibition, revealing structural insights into this mechanism.

Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases

This study investigates the antiviral activity and mechanism of 4'-fluoroadenosine against viral and host polymerases, showing broad-spectrum inhibition and potential for drug development.

Predicting the conformational flexibility of antibody and T-cell receptor CDRs

The paper predicts the structural flexibility of antibody and T-cell receptor CDR3 loops using a new method trained on a large dataset of conformations.

De novo designed pMHC binders facilitate T cell induced killing of cancer cells

This paper designs de novo pMHC binders using generative models to create T cell-based cancer therapeutics with high specificity and minimal cross-reactivity.

Virus glycoprotein nanodisc platform for vaccine design

The paper presents a nanodisc platform for assembling transmembrane glycoproteins into vaccine candidates, demonstrating its utility in HIV vaccine development through structural and functional analyses.

Microbiota-derived secondary bile acids promote STING activation and antitumor activity

This study identifies DCA as a microbiota-derived bile acid that activates STING and enhances antitumor immunity via NK cell activation.

A functionally conserved mechanism of modulation via a vestibule site in pentameric ligand-gated ion channels

The paper identifies a conserved vestibule binding site in pLGICs and shows nanobodies can act as allosteric modulators, expanding drug design possibilities.