Functional repair after ischemic injury through high efficiency in situ astrocyte-to-neuron conversion
Yu‐Chen Chen, Ningxin Ma, Zi-Fei Pei, Zheng Wu, Fabricio H Do Monte, Susan H. Keefe, Emma Yellin, Miranda S. Chen, Jiu-Chao Yin, Grace Lee, Angelica M. Minier-Toribio, Yi Hu, Yu-Ting Bai, Kathryn A. Lee, Gregory J. Quirk, Gong Chen
This study demonstrates high-efficiency in situ astrocyte-to-neuron conversion in adult mammalian brains to repair ischemic injury, generating sufficient new neurons to cover 40% of lost neurons and improve motor and memory function.
Molecular Therapy · Sep 6, 2019Peer-reviewedNeuroscience