Zheng Wu

This study shows that reducing endogenous tau in C. elegans mitigates APOE4-induced behavioral and axonal defects, suggesting a role for tau in AD-related neurodegeneration patterns.

This study shows that high-dose AAV injection in mice induces neutralizing antibodies that limit subsequent AAV infections, with B cells playing a key role.

This study shows that enhancing NeuroD1 expression can convert astrocytes into neurons in mice, but lineage-traced astrocytes require stronger conversion signals.

This study demonstrates high-efficiency in situ astrocyte-to-neuron conversion in adult mammalian brains to repair ischemic injury, generating sufficient new neurons to cover 40% of lost neurons and improve motor and memory function.

This study creates a mouse model with a patient-derived NLGN2 R215H mutation, showing GABAergic deficits and schizophrenia-like behaviors.