Transcriptionally Active HIV Reservoirs Enriched for Interferon-Inducible APOBEC3-Related Mutational Signatures Associate with Arterial Inflammation
Kazuo Suzuki, Angelique Levert‐Mignon, Emma Yoo, Shady Abohashem, John James Zaunders, Lucette A. Cysique, Hirotaka Ode, Yasumasa Iwatani, Ahmed A Tawakol, Priscilla Y. Hsue, Felicia C. Chow, Bruce James Brew
This study finds that APOBEC3-associated premature stop codon signatures in HIV reservoirs are linked to aortic inflammation in ART-suppressed individuals, suggesting a role in cardiovascular risk.
bioRxiv · Jun 8, 2026 · PreprintMolecular Biology