Hirotaka Ode

This study finds that APOBEC3-associated premature stop codon signatures in HIV reservoirs are linked to aortic inflammation in ART-suppressed individuals, suggesting a role in cardiovascular risk.

The paper investigates how transcriptionally active HIV-1 reservoirs with APOBEC3-associated mutational signatures affect neuroaxonal integrity in individuals on suppressive antiretroviral therapy.

The paper shows lenacapavir binding to immature Gag leads to non-infectious giant HIV-1 virions with altered structure and function.