Bruce James Brew

This study finds that APOBEC3-associated premature stop codon signatures in HIV reservoirs are linked to aortic inflammation in ART-suppressed individuals, suggesting a role in cardiovascular risk.

The paper investigates how transcriptionally active HIV-1 reservoirs with APOBEC3-associated mutational signatures affect neuroaxonal integrity in individuals on suppressive antiretroviral therapy.

The paper introduces IL-VIS, a machine learning pipeline that incrementally learns and visualizes progression trajectories for longitudinal data, demonstrating its utility on brain organoid electrophysiological data.

This study finds smaller limbic brain volumes are associated with greater immunosuppression in HIV+ adults across five continents.