Chemotherapy-induced multicellularity drives drug-tolerant persistence state in tumor cells
Jing Li, Z G Zhu, Entong Zheng, Ji Xiong, Aiping Liu, Tingting Hu, Zhan Ma, Chunfang Liu
The paper shows chemotherapy stress converts single cancer cells into multicellular spheroids, creating drug-tolerant persistence, which can be reversed and is suppressed by blocking PGC specification.
bioRxiv · Jul 10, 2026 · PreprintCancer Biology