Cancer BiologybioRxivPreprint
Chemotherapy-induced multicellularity drives drug-tolerant persistence state in tumor cells
Jing Li, Z G Zhu, Entong Zheng…·Chunfang Liu
The paper shows chemotherapy stress converts single cancer cells into multicellular spheroids, creating drug-tolerant persistence, which can be reversed and is suppressed by blocking PGC specification.
DOI 10.64898/2026.07.09.737606