Disrupted mannosidase enzymes in C9orf72 ALS/FTD
Briana N Ondatje, Lauren M Gittings, Kim R Preller, Eric Alsop, Krystine Garcia-Mansfield, Nate Hansen, Brooke Lovell, Ritin Sharma, Ignazio S Piras, Melissa Martinez, Bessie Meechoovet, Anna Bonfitto, Serena Song, Jennifer Levy, Matt Huentelman, , Rita Sattler
The paper identifies reduced Golgi enzymes MAN1A1 and MAN1A2 in ALS-associated microglia and astrocytes, linking impaired glycan metabolism to neuroinflammation and disease mechanisms.
bioRxiv · Nov 4, 2026 · PreprintNeuroscience