Ritin Sharma

The paper identifies reduced Golgi enzymes MAN1A1 and MAN1A2 in ALS-associated microglia and astrocytes, linking impaired glycan metabolism to neuroinflammation and disease mechanisms.

This study uses subcellular spatial proteomics to map protein localization in Capsaspora owczarzaki, a close animal relative, identifying 3,106 high-confidence localizations across 13 compartments.

This study uses subcellular spatial proteomics to map protein localization in Cafeteria roenbergensis, identifying 2,945 proteins across 14 compartments.

This study creates the first global subcellular localization map of Dictyostelium discoideum proteins using subcellular fractionation and mass spectrometry, identifying 3,169 high-confidence localizations across 17 compartments.

This study identifies a tRNA-derived small RNA that reduces cardiac fibrosis and hypertrophy through cell-type-specific mechanisms in mouse and human cardiac cells.

This study uses multi-omic profiling of synaptosomes to identify molecular changes in C9-FTD, revealing disrupted synaptic pathways and localized cryptic transcripts.

The paper develops a pipeline for protein-level cell annotation in human PBMCs using mass spectrometry-based single-cell proteomics and validates it on unsorted samples.

This study uses human placental organoids to investigate trophoblast subtypes' roles in modulating maternal immune responses and shows 3D culture affects immunomodulation differently than 2D culture.

This study uses engineered 3D hydrogels to generate placental organoids and shows they support trophoblast viability and differentiation comparable to Matrigel.

This study shows SYNGAP1, an autism risk gene, is expressed in human cortical progenitors and its dysfunction disrupts neurogenesis and cortical lamination.