Modulatory Effects of M3 Muscarinic Acetylcholine Receptor on Inflammatory Profiles of Human Memory T Helper Cells
Fatemeh Gholizadeh, Mehri Hajiaghayi, Jennifer S. Choi, Samuel R. Little, Niloufar Rahbari, Melika Kargar, Kelly Brotto, Eric Han, Steve C. C. Shih, Peter John Darlington
This study shows that M3R activation in memory Th cells increases pro-inflammatory cytokines like IFN-γ and IL-17A while reducing IL-4, suggesting M3R as a target for modulating immune responses.
The Journal of Immunology · May 22, 2025Peer-reviewedImmunology