Samuel R. Little

Modulatory Effects of M3 Muscarinic Acetylcholine Receptor on Inflammatory Profiles of Human Memory T Helper Cells

This study shows that M3R activation in memory Th cells increases pro-inflammatory cytokines like IFN-γ and IL-17A while reducing IL-4, suggesting M3R as a target for modulating immune responses.

A Digital Microfluidic Platform for the Microscale Production of Functional Immune Cell Therapies

This paper compares a digital microfluidic electroporation system (triDrop) with commercial systems for engineering human T cells, showing improved viability, efficiency, and reduced dysregulation of pathways.

β2-Adrenergic Biased Agonist Inhibits the Development of Th17 and the Response of Memory Th17 Cells in an NF-κB-Dependent Manner.

This study shows that nebivolol, a β2-adrenergic biased agonist, suppresses IL-17A production by memory Th17 cells through a non-canonical β2AR signaling pathway involving NF-κB inhibition.