β2-Adrenergic Biased Agonist Inhibits the Development of Th17 and the Response of Memory Th17 Cells in an NF-κB-Dependent Manner.
Mehri Hajiaghayi, Fatemeh Gholizadeh, Eric Han, Samuel R. Little, Niloufar Rahbari, Isabella Ardila, Carolina Lopez Naranjo, Kasra Tehranimeh, Steve C. C. Shih, Peter John Darlington
This study shows that nebivolol, a β2-adrenergic biased agonist, suppresses IL-17A production by memory Th17 cells through a non-canonical β2AR signaling pathway involving NF-κB inhibition.
Frontiers in Immunology · Oct 9, 2024Peer-reviewedImmunology