Transposon insertion causes ctnnb2 transcript instability that results in the maternal effect zebrafish ichabod (ich) mutation
Zsombor Varga, Ferenc Kagan, Shingo Maegawa, Ágnes Nagy, Javan Okendo, Shawn Michael Burgess, Eric S. Weinberg, Máté Varga
The paper identifies a transposon insertion in the 3UTR of ctnnb2 as the cause of the maternal-effect ich mutation in zebrafish, leading to transcript instability and ventralized embryos.
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · Jul 1, 2025Peer-reviewedDevelopmental Biology