Shawn Michael Burgess

The paper presents a new zebrafish genome assembly with increased sequence coverage and improved annotation, along with a pangenome resource for variant analysis.

The paper identifies a transposon insertion in the 3UTR of ctnnb2 as the cause of the maternal-effect ich mutation in zebrafish, leading to transcript instability and ventralized embryos.

This study identifies tnfrsfa as essential for maintaining the stem cell niche in zebrafish neuromasts and supporting hair cell regeneration through NF-κB signaling and Sox2 expression.

This study identifies a population of neurons in the axolotl brain that, when activated by tail amputation, promote spinal cord regeneration by stimulating hormone production.

This study shows Stat3 has distinct roles in zebrafish PLL axon growth during development and regeneration, with mitochondrial function in growth and Jak/Stat signaling in regeneration.

The paper reports the reference genome of the paradise fish (Macropodus opercularis) using long-read sequencing, identifying 20,157 protein-coding genes and demonstrating high completeness.

The paper identifies a high-density miR-430 promoter cluster that forms a transcription body, enabling early gene activation during the minor wave of zygotic genome activation in zebrafish.

The paper creates a central repository for zebrafish developmental genomics data, identifies new cis-regulatory elements, and compares regulatory elements between zebrafish and mouse.

This study shows that inhibiting STAT3 reduces VEGF-induced vascular permeability in zebrafish, mice, and human endothelium, suggesting a therapeutic target for diseases involving vascular leakage.

This study develops a method to induce hair cell ablation in zebrafish and shows that these cells regenerate in vivo.

This study shows that Fmn2b is essential for motor neuron development and function in zebrafish, with loss-of-function leading to motor deficits and impaired axon branching.

This study identifies Fmn2's role in zebrafish neural circuit development, specifically in the formation of spiral fiber neurons critical for the acoustic startle response.

This study shows that cnr2 is critical for ribbon synapse maturation and function in hair cells and photoreceptors, affecting synaptic structure and behavior in zebrafish larvae.

The paper generates zebrafish CRISPR mutants for DNA repair genes and identifies their roles in development and disease.

This study characterizes the sex determination system and sex chromosomes in goldfish, identifying a large non-recombining region on linkage group 22 as the likely Y chromosome and developing sex-linked genetic markers.

This study shows that appb mutation in zebrafish causes early developmental defects but allows normal adult development, suggesting compensation by other app family members.

The paper identifies gemin3 as a regeneration-essential gene in zebrafish and shows smn1, gemin3, and gemin5 inhibit the ErbB pathway to promote cell proliferation during tissue regeneration.

This paper presents a high-quality goldfish genome assembly and analyzes gene evolution after whole genome duplication, identifying gene divergence patterns across tissues.

The paper describes a zebrafish gene break transposon library for genomic discovery and disease modeling, identifying novel gene expression patterns and generating models for human disease loci.

This study uses zebrafish models to show that AK2 deficiency impairs sensory hair cell development and regeneration, induces oxidative stress, and can be partially rescued by glutathione treatment.

This study shows that Cpf1 can achieve high gene targeting rates in mice, sometimes surpassing Cas9, but requires higher mRNA and guide concentrations.