Endothelial cell Pannexin1 overexpression impairs ischemic stroke outcome in a sex-dependent manner
Maria Tomàs Gracia, Amanda K. Mauro, Colleen K. Duffy, Eric Y Dai, Guleer H Shahab, Christopher B. Medina, Kodi S. Ravichandran, Brant E. Isakson, Miranda Elizabeth Good
This study shows that overexpressing Pannexin1 in endothelial cells worsens ischemic stroke outcomes specifically in female mice, suggesting a sex-dependent role in vascular function and stroke recovery.
bioRxiv · Feb 7, 2025 · PreprintPhysiology