PhysiologybioRxivPreprint
Endothelial cell Pannexin1 overexpression impairs ischemic stroke outcome in a sex-dependent manner
Maria Tomàs Gracia, Amanda K. Mauro, Colleen K. Duffy…·Miranda Elizabeth Good
This study shows that overexpressing Pannexin1 in endothelial cells worsens ischemic stroke outcomes specifically in female mice, suggesting a sex-dependent role in vascular function and stroke recovery.
DOI 10.1101/2025.02.07.636909