Brant E. Isakson

Pannexin 1 Ablation Disrupts Cell Cycle Progression and Compromises the Structure of Melanoma Tumours

This study shows that PANX1 ablation disrupts cell cycle progression and tumor structure in melanoma, suggesting it as a therapeutic target.

Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes

This study identifies that PANX1 Y198 phosphorylation mediates ATP release, driving β-adrenergic vasoconstriction in vascular smooth muscle cells.

Multimodal analysis identifies pericyte-centered signaling programs altered by sex and brain region in Alzheimer's Disease

The paper identifies sex- and brain region-specific pericyte signaling changes in Alzheimer's Disease using single-nucleus RNA sequencing and spatial transcriptomics.

Suppression of non-canonical autophagy induces endothelial and cardiac dysfunction

This study shows that disrupting non-canonical autophagy (LANDO) impairs endothelial and cardiac function by disrupting VEGFR2 recycling and Hb- expression.

Arterial iron regulates vasodilation during anemia via endothelial holo-alpha globin

This study shows arterial iron deficiency affects vasodilation by altering endothelial holo-alpha globin levels and NO signaling in female mice, but not in males.

Injury Induced Connexin 43 Expression Regulates Endothelial Wound Healing

This study shows that injury-induced Cx43 upregulation in endothelial cells promotes wound healing through gap junction-mediated communication, with phosphorylation playing a key role.

A connexin 43 targeting peptide prevents blood vessel neointima formation

This study identifies a Cx43 targeting peptide that inhibits neointima formation in both human and mouse models by blocking cyclin E interactions and cell cycle progression.

Hypoxia-Induced Metabolic Reprogramming and Markings of Cell Fate in Concentric Arterial Hypertrophy

This study identifies renin-lineage cell fate reprogramming and metabolic dysfunction as drivers of concentric arterial hypertrophy, with potential biomarkers for early detection.

Nitrosation of CD36 regulates endothelial function and serum lipids

The paper shows nitrosation of CD36 by nitric oxide prevents endothelial lipid uptake and maintains function in obesity.

Endothelial cell Pannexin1 overexpression impairs ischemic stroke outcome in a sex-dependent manner

This study shows that overexpressing Pannexin1 in endothelial cells worsens ischemic stroke outcomes specifically in female mice, suggesting a sex-dependent role in vascular function and stroke recovery.

Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target

This study evaluates a novel S1P transport blocker, SLF80821178, showing efficacy in multiple sclerosis without the cardiac side effects of SRMs, but with less lymphopenia and unchanged lymph S1P levels.

Novel carboxy-terminal Pannexin 1 isoform is expressed in mouse melanoma cells and interacts with the full-length protein

Loss of endothelial cell heterogeneity in arteries after obesogenic diet

The paper investigates how an obesogenic diet affects endothelial cell heterogeneity in arteries, finding convergence in transcriptional profiles between mesenteric and adipose arterial endothelial cells in obesity.

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling

The paper identifies capillary-associated microglia (CAMs) and shows they regulate vascular structure and function via PANX1-P2RY12 signaling.

Brain Endothelial Cell TRPA1 Channels Initiate Neurovascular Coupling

The paper identifies TRPA1 channels in brain capillary endothelial cells as key initiators of neurovascular coupling by generating retrograde signals that dilate upstream arterioles.