Sensorineural regulation of skull healing implicates FGF1 signaling in non-healing bone
Allison L Horenberg, Carlos U. Villapudua, Mingxin Xu, Eric Z. Zeng, Shaquielle Dias, Tanishk Sinha, Mary Archer, Erica L. Scheller, Arvind P. Pathak, Aaron Watkins James, Warren L. Grayson
The paper identifies FGF1 signaling as a sensorineural-skeletal interaction that impairs bone healing in critical-sized defects by promoting osteoprogenitor proliferation and inhibiting differentiation.
bioRxiv · Nov 24, 2025 · PreprintBioengineering