Mingxin Xu

The paper identifies neurotrophic signals, particularly FGF9, required for fracture healing by mapping somatosensory afferent circuitry to bone and analyzing gene expression changes in DRG neurons.

The paper identifies FGF1 signaling as a sensorineural-skeletal interaction that impairs bone healing in critical-sized defects by promoting osteoprogenitor proliferation and inhibiting differentiation.

This study shows that TrkA+ sensory neurons promote osteosarcoma progression by enhancing tumor growth, vascularization, and metastasis, and that inhibiting these neurons reduces disease severity and improves survival.