Severely lipoatrophic mice are hypermetabolic and hyperthermic under thermoneutral conditions in part due to an enhanced liver de novo lipogenesis
Álbert S. Peixoto, Caroline Antunes Lino, Bianca Franco Leonardi, Érique Castro, Thayna S. Vieira, Julia V França, Ana B. Pires, Natália Monteiro Pessoa, Érika Vicência Monteiro Pessoa, Marina A. Abe‐Honda, Luciano Paulino Silva, Ana Carolina P Baptista, Loreana Sanches Silveira, Maria Luiza Estimo Michalani, Mariana Mesquita, , William T. Festuccia
This study shows that severely lipoatrophic mice are hypermetabolic and hyperthermic at 30°C due to enhanced liver de novo lipogenesis, independent of thyroid hormones or calcium cycling.
bioRxiv · Jun 23, 2026 · PreprintPhysiology