Érique Castro

Constitutive PI3K-AKT activation promotes steatohepatitis through de novo lipogenesis despite enhanced mitochondrial β-oxidation, essential fatty acid depletion and reduced lipid peroxidation

Severely lipoatrophic mice are hypermetabolic and hyperthermic under thermoneutral conditions in part due to an enhanced liver de novo lipogenesis

This study shows that severely lipoatrophic mice are hypermetabolic and hyperthermic at 30°C due to enhanced liver de novo lipogenesis, independent of thyroid hormones or calcium cycling.

Hepatocyte-, but not myeloid cell-Rictor/mTORC2 deficiency moderately attenuates steatotic liver disease induced by intake of a choline-deficient, amino acid-defined high-fat diet

This study shows that hepatocyte-specific mTORC2 deficiency slightly reduces liver disease from a choline-deficient diet, while myeloid cell deficiency has no effect.