Negative allosteric modulation of α5-GABAA receptors engages dynamic cortical glutamatergic and GABAergic mechanisms underlying adaptive behavior in mice
Fernanda Daher, Caio Tabata Fukushima, Erik A. Ingebretsen, Jean M. Bidlack, John R. Atack, M. Oana Popa, Manoela V. Fogaça
This study shows that Basmisanil enhances cortical plasticity and adaptive behaviors in mice by modulating α5-GABAAR, involving glutamatergic and GABAergic mechanisms.
bioRxiv · Jan 16, 2026 · PreprintPharmacology & Toxicology