Early mitochondrial dysfunction proceeds neuroinflammation, synaptic alteration, and autophagy impairment in hippocampus of App knock-in Alzheimer mouse models
Luana Naia, Makoto Shimozawa, Erika Bereczki, Xidan Li, Jianping Liu, Richeng Jiang, Nuno Santos Leal, Catarina Moreira Pinho, Erik Berger, Victoria Lim Falk, Giacomo Dentoni, Maria Ankarcrona, Per Nilsson
This study identifies early mitochondrial dysfunction, neuroinflammation, and autophagy impairment in App knock-in Alzheimer's mouse models through time-course transcriptome analysis.
bioRxiv · Mar 7, 2023 · PreprintNeuroscience