Luana Naia

Modulation of mitochondria-ER contacts decrease inflammasome formation and restores amyloid β-peptide phagocytosis in adult mouse microglia

This study shows that modulating mitochondria-ER contacts reduces inflammasome activation and restores Aβ phagocytosis in AD microglia.

Astrocyte-neuron mitochondrial transfer via mitoEVs supports neuronal energy metabolism and is impaired in early Alzheimer's disease

This study identifies mitoEV-mediated mitochondrial transfer from astrocytes to neurons as a compromised pathway in early Alzheimer's disease, revealing its role in supporting neuronal energy metabolism.

Mitochondria serve as a Holdout Compartment for Aggregation-Prone Proteins hindering Efficient Ubiquitin-Dependent Degradation

This study identifies mitochondrial localization as a barrier to ubiquitin-dependent degradation of aggregation-prone proteins, showing that inhibiting eIF5A reduces mitochondrial retention and enhances degradation.

Early mitochondrial dysfunction proceeds neuroinflammation, synaptic alteration, and autophagy impairment in hippocampus of App knock-in Alzheimer mouse models

This study identifies early mitochondrial dysfunction, neuroinflammation, and autophagy impairment in App knock-in Alzheimer's mouse models through time-course transcriptome analysis.