Per Nilsson

This study shows that SPPL2b deficiency alters synaptic proteome and neuronal function in aging mice, with increased dendritic spine density and behavioral changes.

This study applies a multimodal lifestyle intervention in mice to improve cognition and synaptic plasticity, showing effects comparable to pharmacological interventions.

This study investigates ERβ's role in sex-specific protection against AD pathology in AppNL-G-F mice, finding ERβ activation protects both males and females, with ovariectomy increasing Aβ levels but limited overall pathology effects.

The paper investigates early synaptic dysfunction and emotional behavior in AppNL-F mice, finding reactive astrocytes contribute to synaptic mistuning before Aβ plaques and are linked to depressive-like behavior.

This paper compares Aβ fibril structures in three mouse models of Alzheimer's disease, finding age-dependent differences in plaque morphology and polymorph maturation.

The paper investigates how microglia loss in the hippocampus contributes to early amyloid pathology progression by disrupting neural oscillations and synaptic function in a mouse model.

This study identifies early mitochondrial dysfunction, neuroinflammation, and autophagy impairment in App knock-in Alzheimer's mouse models through time-course transcriptome analysis.

This study shows that SPPL2b affects APP cleavage and has biphasic Aβ-mediated expression in Alzheimer's disease, suggesting it as a potential drug target.

This study identifies α-endosulfine as a negative regulator of neprilysin activity, showing that its deficiency reduces amyloid β42 deposition in Alzheimer's disease models.

This study identifies SST1 and SST4 as redundant regulators of neprilysin, a key amyloid beta-degrading enzyme, and shows that targeting these receptors reduces Aβ pathology and improves cognition in an AD mouse model.