Reciprocal macrophage-MSC crosstalk drives immunomodulatory and regenerative phenotypes in a mineralized collagen scaffold
Vasiliki Kolliopoulos, Maxwell Polanek, Hashni Epa Vidana Gamage, Melisande Wong Yan Ling, Aleczandria S. Tiffany, Erik R. Nelson, Kara L. Spiller, Brendan A.C. Harley
This study shows that MSC-macrophage interactions in a mineralized collagen scaffold drive immunomodulatory and regenerative responses through IL-6 secretion and M2-like macrophage polarization.
Journal of Biomedical Materials Research Part A · Jun 1, 2026Peer-reviewedBioengineering