Kara L. Spiller

This study shows that MSC-macrophage interactions in a mineralized collagen scaffold drive immunomodulatory and regenerative responses through IL-6 secretion and M2-like macrophage polarization.

This study compares non-viral CRISPR delivery methods in stem cells, finding that lipid-based delivery offers high efficiency but risks genomic instability, while CPPs reduce side effects at lower efficiency.

This paper develops a bioinspired oxidized lipid nanoparticle platform for mRNA-based engineering of CAR-Ms to target solid tumors, showing improved delivery and tumor-killing efficacy.

This study shows how scaffold pore size, alignment, and glycosaminoglycan content influence macrophage polarization toward M2-like phenotypes in 3D mineralized collagen scaffolds.

This study examines how injury size affects immune cell dynamics in muscle repair, finding early macrophage dysfunction and increased neutrophils in fibrotic outcomes.

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.